J Korean Ophthalmol Soc > Volume 53(6); 2012 > Article
Journal of the Korean Ophthalmological Society 2012;53(6):856-860.
DOI: https://doi.org/10.3341/jkos.2012.53.6.856    Published online June 15, 2012.
A Case of Localized Merkel Cell Carcinoma on the Upper Eyelid.
Woo Seok Lee, Sang Won Kim, Joo Heon Roh
Sungmo Eye Hospital, Busan, Korea. rhoahn@yahoo.co.kr
상안검에 국한되어 발생한 Merkel 세포 종양 1예
Sungmo Eye Hospital, Busan, Korea
To report a case of Merkel cell carcinoma on the left upper eyelid without metastasis and its immunohistochemical features. The carcinoma was successfully treated with excisional surgery and prophylactic radiation therapy. CASE SUMMARY: A 76-year-old woman presented to the hospital complaining of a 0.6 x 0.9-cm-sized painless and purplish-red colored mass that had grown rapidly on her left upper eyelid margin over the previous two months. An excisional biopsy was performed. On immunohistochemical examination of the lesion, the tumor cells expressed immunoreactivity for synaptophysin and were negative for LAC and cytokeratin, confirming the diagnosis of Merkel cell carcinoma. Additional surgery was performed because the surgical margins were positive. No other primary or metastatic lesions were found. The patient was treated with local prophylactic irradiation and remained disease-free at her 10-month follow-up visit.
Key Words: Eyelid mass;Immunohistochemical study;Merkel cell carcinoma;Neuroendocrine tumor;Synaptophysin

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