J Korean Ophthalmol Soc > Volume 48(12); 2007 > Article
Journal of the Korean Ophthalmological Society 2007;48(12):1654-1662.
DOI: https://doi.org/10.3341/jkos.2007.48.12.1654    Published online December 31, 2007.
Short-term Effects and Side Effects of Tacrolimus for Behcet's Uveitis.
Jun Woong Moon, Su Jeong Song, Bo Kyung Koo, Young Min Cho, Hyeong Gon Yu
1Department of Ophthalmology, College of Medicine and Medical Research Center, Seoul National University, Seoul, Korea. hgonyu@snu.ac.kr
2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
베체트 포도막염에 대한 타크로리무스(Tacrolimus)의 단기 효과와 합병증
문준웅1,송수정1,구보경2,조영민2,유형곤1
Department of Ophthalmology, College of Medicine and Medical Research Center, Seoul National University1, Seoul, Korea Department of Internal Medicine, Seoul National University College of Medicine2, Seoul, Korea
Correspondence:  Hyeong Ggon Yu, M.D. Ph.D.
Abstract
PURPOSE
To investigate the clinical effects and side effects of Tacrolimus for ocular Behcet's disease. METHODS: Eight patients (male: 5, age: 35+/-7.5 (25-48) years) with Behcet's uveitis, refractory posterior uveitis unresponsive to combination treatment with cyclosporine, azathioprine, and oral steroid or significant cyclosporine-related adverse effects were recruited prospectively, and cyclosporine was switched to Tacrolimus. Visual acuity, degree of anterior chamber, and vitreous haze were compared before the conversion and three months after. Oral glucose tolerance, plasma insulin, cholesterol, creatinine, and aspartate (AST)/alanine aminotransferase (ALT) were measured to monitor systemic effects. RESULTS: Visual acuity did not change significantly after conversion to Tacrolimus. Anterior chamber (seven patients) and vitreous (four patients) inflammation were found before conversion and decreased or disappeared after conversion. Overall plasma levels of glucose, insulin, creatinine, and AST/ALT were similar before and after conversion. However, cholesterol was significantly decreased after conversion (p=0.028). One patient developed diabetes mellitus. CONCLUSIONS: Tacrolimus may be effective for Behcet's uveitis unresponsive to or intolerable of traditional treatments. In addition, periodic monitoring for side effects, such as hyperglycemia and diabetes mellitus, may be necessary.
Key Words: Behcet's uveitis;Cyclosporine;Tacrolimus


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