| Prognosis and Disorganization of Retinal Inner Layers in Central Retinal Vein Occlusion with Dexamethasone Implantation. |
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Hyun Ji Kang, Yong Wun Cho, Byeong Sun Kim, Ji Sung Jeong, Jong Moon Park, In Young Chung, Woong Sun Yoo |
1Department of Ophthalmology, Gyeongsang National University College of Medicine, Jinju, Korea. oocee@hanmail.net
2Department of Ophthalmology, Gyeongsang National University Hospital, Jinju, Korea.
3Institute of Health Sciences, Gyeongsang National University, Jinju, Korea. |
| 망막중심정맥폐쇄의 덱사메타손삽입술 치료에서 망막내층손상과 예후와의 관계 |
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강현지1 · 조용운1,2 · 김병선1,2 · 정지성1,2 · 박종문1,2,3 · 정인영1,2,3 · 유웅선1,2,3 |
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경상대학교 의과대학 안과학교실1, 경상대학교병원 안과2, 경상대학교 건강과학연구원3 |
Correspondence:
Woong-Sun Yoo, MD
Email: oocee@hanmail.net |
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Received: 22 May 2019 • Revised: 3 June 2019 • Accepted: 24 October 2019 |
| Abstract |
PURPOSE
To examine whether disorganization of retinal inner layers (DRILs) at baseline and after treatment was associated with visual acuity in patients with macular edema secondary to central retinal vein occlusion (CRVO) who were treated with intravitreal dexamethasone implants. METHODS: A retrospective review of records of 22 patients with treatment-naive CRVO with centrally involved macular edema treated with intravitreal dexamethasone implants. Spectral domain-optical coherence tomography images were obtained during each visit. The DRIL extent and additional parameters were evaluated in a 2,000 µm-wide foveal centered area. RESULTS: In the 22 patients (74.5 ± 8.92 years), baseline DRIL was observed in 21 eyes (94.5%). Using univariate analysis, baseline best corrected visual acuity (BCVA) was significantly associated with the extent of baseline DRIL (p = 0.005, r = −0.58), and the extent of external limiting membrane disruption and ellipsoid zone (p = 0.015, r = −0.51; p = 0.011, r = −0.533, respectively). The final BCVA was significantly correlated with the baseline BCVA (p < 0.001, r = 0.74) and extent of DRIL (p = 0.04, r = −0.35). Changes in the BCVA were correlated with changes of DRIL between baseline and the final visit (p = 0.041, r = 0.439). CONCLUSIONS: The extents of baseline DRIL and DRIL changes after treatment with intravitreal dexamethasone implants for macular edema secondary to CRVO may be useful parameter for visual acuity improvement. |
| Key Words:
Dexamethasone;Disorganization of retinal inner layers;Macular edema;Retinal vein occlusion |
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