Anti-pseudomonal Effect of a Nephrite-containing Contact Lens Storage Case.

Lee, Sang Min; Jung, Jae Woo; Lee, Dong Hyun; Park, Sung Hee; Lee, Jong Heon; Yu, Hak Sun; Kim, Yoon Kyung; Lee, Ji Eun

doi:2018.59.8.724

J Korean Ophthalmol Soc > Volume 59(8); 2018 > Article

Original Article

Journal of the Korean Ophthalmological Society 2018;59(8):724-729.
DOI: https://doi.org/10.3341/jkos.2018.59.8.724 Published online August 15, 2018.

Anti-pseudomonal Effect of a Nephrite-containing Contact Lens Storage Case.

Sang Min Lee, Jae Woo Jung, Dong Hyun Lee, Sung Hee Park, Jong Heon Lee, Hak Sun Yu, Yoon Kyung Kim, Ji Eun Lee

¹Department of Ophthalmology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea. jiel75@hanmail.net
²Department of Parasitology and Tropical Medicine, Pusan National University School of Medicine, Yangsan, Korea.
³Department of Optometry, Busan Women's College, Busan, Korea.
⁴Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea.

연옥이 첨가된 콘택트렌즈 보관용기의 항녹농균 효과

이상민¹⋅정재우¹⋅이동현¹⋅박성희²⋅이종헌¹⋅유학선²⋅김윤경³⋅이지은^1,4

부산대학교 의학전문대학원 양산부산대학교병원 안과학교실¹, 부산대학교 의학전문대학원 기생충학 및 열대의학교실², 부산여자대학교 안경광학과³, 부산대학교 의학전문대학원 양산부산대학교병원 의생명융합연구소⁴

Correspondence: Ji-Eun Lee
Email: jiel75@hanmail.net

Received: 14 February 2018 • Revised: 20 May 2018 • Accepted: 20 July 2018

Abstract

PURPOSE
To compare the anti-pseudomonal effect of nephrite-containing contact lens (CL) storage cases with conventional CL storage cases. METHODS: The degree of proliferation and adhesion of Pseudomonas aeruginosa (P. aeruginosa) on 1st–3rd generation silicone hydrogel contact lenses (SHCLs) was compared by using both 5% nephrite-containing CL storage cases and conventional CL storage cases. The degree of adhesion of P. aeruginosa to the CL was also compared in 1% or 5% nephrite solution and multipurpose solution (MPS). RESULTS: Nephrite-containing CL storage cases showed a significant inhibitory effect on P. aeruginosa proliferation (p = 0.03) and significantly reduced the number of adherent P. aeruginosa on all 1st–3rd generation SHCLs compared with conventional CL storage cases (p = 0.02, p = 0.03, and p < 0.01, respectively). There was no significant anti-pseudomonal effect of 1% and 5% nephrite solutions compared with MPS. CONCLUSIONS: Nephrite may be the next generation substance that reduces infectious keratitis caused by P. aeruginosa when added to CL storage cases.

Key Words: Contact lens storage case;Infectious keratitis;Multipurpose solution;Nephrite;Pseudomonas aeruginosa