| Diagnostic Accuracies of Bruch Membrane Opening-minimum Rim Width and Retinal Nerve Fiber Layer Thickness in Glaucoma. |
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So Hee Kim, Keun Heung Park, Ji Woong Lee |
1Department of Ophthalmology, Pusan National University School of Medicine, Busan, Korea. glaucoma@pnu.ac.kr
2Biomedical Research Institute, Pusan National University Hospital, Busan, Korea. |
| 원발개방각녹내장 환자에서 브루크막 개방 최소 시신경 유두테 폭과 망막신경섬유층 두께의 진단력 비교 |
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김소희1⋅박건형1⋅이지웅1,2 |
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부산대학교 의과대학 안과학교실1, 부산대학교병원 의생명연구원2 |
Correspondence:
Ji Woong Lee,
Email: glaucoma@pnu.ac.kr
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Received: 6 April 2017 • Revised: 17 June 2017 • Accepted: 30 June 2017 |
| Abstract |
PURPOSE
To compare the diagnostic capability of Bruch membrane opening-minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness for the detection of primary open angle glaucoma. METHODS: Spectral-domain optical coherence tomography (SD-OCT) with 24 radial and 1 peripapillary B-scans centered on the Bruch membrane opening (BMO) was performed. Two SD-OCT parameters were computed globally and sectorally: (1) BMO-MRW, the minimum distance between BMO and internal limiting membrane; and (2) peripapillary retinal nerve fiber layer (RNFL) thickness. The diagnostic performance of BMO-MRW and RNFL thickness were compared with receiver operating characteristic (ROC) analysis globally and sectorally. Areas under the ROC (AUC) were calculated and compared. RESULTS: One hundred fourteen eyes (52 healthy, 62 glaucomatous) of 114 participants were included. In global analyses, the performance of BMO-MRW was similar to that of RNFL thickness (AUC 0.95 [95% confidence interval {CI}, 0.91-0.99], and 0.95 [95% CI, 0.91-0.99], respectively, p=0.93). In sectoral analyses, the pair-wise comparison among the ROC curves showed no statistical difference for all sectors except for the superotemporal, superonasal, and nasal sectors, which had significantly larger AUCs in BMO-MRW compared to RNFL thickness (p=0.03, p<0.001, and p=0.03, respectively). The parameter with the largest AUC was the inferotemporal sector for both BMO-MRW and RNFL thickness (AUC 0.98 [95% CI, 0.96-1.00], and 0.98 [95% CI, 0.96-1.00], respectively, p=0.99). CONCLUSIONS: Global BMO-MRW performed as well as global RNFL thickness for detection of glaucoma. In superotemporal, superonasal and nasal sectors, regional BMO-MRW performed better than regional RNFL thickness. |
| Key Words:
Bruch membrane opening-minimum rim width;Diagnostic capability;Peripapillary retinal nerve fiber layer thickness;Spectral-domain optical coherence tomography |
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