Analysis of Aqueous Humor Cytokines in Diabetic Retinopathy.

Song, Young Jin; Jung, Jong Hyun; Kim, Do Gyun

doi:2014.55.12.1821

J Korean Ophthalmol Soc > Volume 55(12); 2014 > Article

Original Article

Journal of the Korean Ophthalmological Society 2014;55(12):1821-1827.
DOI: https://doi.org/10.3341/jkos.2014.55.12.1821 Published online December 15, 2014.

Analysis of Aqueous Humor Cytokines in Diabetic Retinopathy.

Young Jin Song, Jong Hyun Jung, Do Gyun Kim

Department of Ophthalmology, Myongji Hospital, Kwandong University College of Medicine, Goyang, Korea. kimdk89@empas.com

당뇨망막병증의 전방수내 사이토카인 분석

송영진⋅정종현⋅김도균

Department of Ophthalmology, Myongji Hospital, Kwandong University College of Medicine, Goyang, Korea

Abstract

PURPOSE
To investigate the relationship between the concentration of aqueous humor cytokines and the severity of diabetic retinopathy. METHODS: Thirty-six subjects were included in the control, non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR) groups, each group has 12 patients. Aqueous levels of cytokines (interleukin (IL)-1alpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, vascular endothelial growth factor (VEGF), monocyte chemoattractant protein (MCP)-1, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha) were investigated according to the severity of diabetic retinopathy. RESULTS: When the control group was compared with the PDR and NPDR groups, aqueous levels of IL-6 were significantly higher in PDR patients than in those of both the control and NPDR groups (p = 0.016 and p = 0.003, respectively). The aqueous levels of VEGF were significantly higher in the eyes of PDR patients than in those of the control group (p = 0.003). There were no statistically significant differences between the 3 groups with regard to other cytokines. CONCLUSIONS: Aqueous levels of IL-6 and VEGF were higher in the eyes of PDR patients than in those of healthy controls.

Key Words: Aqueous humor;Cytokine;Diabetic retinopathy