J Korean Ophthalmol Soc > Volume 50(1); 2009 > Article
Journal of the Korean Ophthalmological Society 2009;50(1):51-60.
DOI: https://doi.org/10.3341/jkos.2009.50.1.51    Published online January 15, 2009.
Short-term Efficacy of Intravitreal Bavacizumab for Polypoidal Choroidal Vasculopathy.
Min Ho Lee, Jin Hwan An, Ji Eun Lee, Boo Sub Oum
Department of Ophthalmology, Pusan National University Hospital, College of Medicine, Pusan, Korea. bsoum@pusan.ac.kr
결절맥락막혈관병증에서 유리체강내 베바시주맙 주입술의 단기 효과
이민호ㆍ안진환ㆍ이지은ㆍ엄부섭
Department of Ophthalmology, Pusan National University Hospital, College of Medicine, Pusan, Korea
Abstract
PURPOSE
To evaluate the short-term effect of intravitreal bevacizumab (Avastin(R)) in polypoidal choroidal vasculopathy. METHODS: Intravitreal Avastin(R) was injected into 13 eyes of 13 patients with PCV in this retrospective, interventional case study. The follow-up period lasted over 3 months after therapy. Changes in best-corrected visual acuity (BCVA), foveal height determined by optical coherence tomography, and abnormal vasculature in indocyanine green angiography (ICGA) were evaluated. RESULTS: The mean LogMAR BCVA was 0.82 at baseline, 0.78 at 1 month after treatment, and 0.73 at 3 months after treatment. Visual acuity was stabilized or improved in 13 eyes (100%). The mean foveal height was 288 micrometer at baseline, 231 micrometer (p<0.05) at 1 month after treatment, and 196 micrometer at 3 months after treatment. The polypoidal lesions in ICGA decreased in 4 eyes (31%), although branching vasculature in ICGA was unchanged in 13 eyes (100%). CONCLUSIONS: Intravitreal injection of Avastin(R) may stabilize visual acuity and reduce macular edema due to decreased retinal pigment epithelial detachment and leaking. However, intravitreal injection had a minimal effect in occlusion of the symptomatic polypoidal lesions and no effect in occlusion of the branching vascular network.
Key Words: Bevacizumab;Polypoidal choroidal vasculopathy


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