Tear Film and Ocular Surface Changes in Chronic Renal Failure Patients Undergoing Hemodialysis.

Lee, Seung Hyun; Kim, Hyo Rin; Yoon, Kyung Chul

doi:2009.50.8.1167

J Korean Ophthalmol Soc > Volume 50(8); 2009 > Article

Original Article

Journal of the Korean Ophthalmological Society 2009;50(8):1167-1173.
DOI: https://doi.org/10.3341/jkos.2009.50.8.1167 Published online August 15, 2009.

Tear Film and Ocular Surface Changes in Chronic Renal Failure Patients Undergoing Hemodialysis.

Seung Hyun Lee, Hyo Rin Kim, Kyung Chul Yoon

¹Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea. kcyoon@chonnam.ac.kr
²Department of Public Health, Graduate School Chonnam National University, Gwangju, Korea.

혈액투석 중인 만성신부전 환자에서 눈물막 및 안구표면의 변화에 관한 연구

이승현¹ㆍ김효린²ㆍ윤경철¹

Department of Ophthalmology, Chonnam National University Medical School¹, Gwangju, Korea / Department of Public Health, Graduate School Chonnam National University², Gwangju, Korea

Abstract

PURPOSE
To evaluate the changes of tear film and ocular surface in patients with chronic renal failure (CRF) undergoing hemodialysis. METHODS: In 50 eyes of 25 CRF patients undergoing hemodialysis and 30 eyes of 15 control subjects, tear break-up time (BUT), basal tear secretion (BST), corneal sensation, tear clearance rate (TCR), keratoepitheliopathy and impression cytology findings were compared. Correlation between the above parameters and local or systemic factors was analyzed. RESULTS: Tear BUT, BST, TCR, conjunctival squamous metaplasia and conjunctival goblet cell density in the patient and control groups were 7.7+/-3.8 and 11.1+/-2.9 sec, 7.0+/-3.1 and 14.0+/-6.2 mm, 3.5+/-1.2 and 4.5+/-0.7, 1.5+/-0.6 and 0.3+/-0.5, 6.5+/-1.7 and 24.3+/-21.4 cells/mm2. Osmolarity in serum and tears of the patient group was higher than that of the control group. Serum and tear osmolarity correlated with BST, corneal sensation and conjunctival goblet cell density, and serum creatine level correlated with conjunctival goblet cell density (p<0.05). CONCLUSIONS: Patients with CRF undergoing hemodialysis have an increased risk of dry eye and thus, serum and tear osmolarity in dry eye patients should be closely monitored.

Key Words: Chronic renal failure;Dry eye syndrome