Two Cases of Klebsiella Pneumoniae Endogenous Endophthalmitis Treated with Sulperazone.

Lee, Young Rok; Kim, Yun Ho; Hahm, Kyoung Hoon; Shin, Min Cheol

Case Report

Journal of the Korean Ophthalmological Society 2005;46(3):554-559.
Published online March 31, 2005.

Two Cases of Klebsiella Pneumoniae Endogenous Endophthalmitis Treated with Sulperazone.

Young Rok Lee, Yun Ho Kim, Kyoung Hoon Hahm, Min Cheol Shin

Department of Ophthalmology, College of Medicine, Hallym University, Chunchon, Korea. mcshin@hallym.ac.kr

설페라존을 사용하여 치료한 크렙시엘라 뉴모니아 내인성 안내염 2예

이영록,김윤호,함경훈,신민철

Department of Ophthalmology, College of Medicine, Hallym University, Chunchon, Korea

Correspondence: Min-Cheol Shin, M.D.

Abstract

PURPOSE
To report and review 2 cases of Klebsiella Pneumoniae endogenous endophthalmitis showing multi drug resistance that were treated with sulperazone. METHODS: Sulperazone was administered to two patients with Klebsiella Pneumoniae endogenous endophthalmitis: a 51-year-old male with orbital cellulitis who showed no response to vancomycin, ceftazidime, and amikacin for 6days; and a 67-year-old female who showed no response to cefotaxime, and amikacin. RESULTS: Proptosis and inflammation began to improve after changing to sulperazone. Therefore, enucleation and debridement could be avoided. CONCLUSIONS: Good results were obtained by use of Sulperazone which inactivates beta-lactamase irreversibly and which showed bactericidal effect to multi drug resistant Klebsiella Pneumoniae endogenous endophthalmitis.

Key Words: Endogenous endophthalmitis;Klebsiella Pneumoniae;Sulperazone