| Incidence and Risk Factors of Retinopathy of Prematurity in Premature Twins. |
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Joo Youn Oh, Seong Joon Kim, Young Suk Yu, Jung Hwan Choi |
1Department of Ophthalmology, Seoul National University College of Medicine, Korea. ysyu@snu.ac.kr
2Seoul Artificial Eye Center Seoul National University Hospital Clinical Research Institute, Korea.
3Department of Pediatrics, Seoul National University College of Medicine, Korea. |
| 쌍태아에서 미숙아망막병증의 발생율과 위험인자 |
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오주연 ( O Ju Yeon ) , 김성준 ( Kim Seong Jun ) , 유영석 ( Yu Yeong Seog ) , 최중환 ( Choe Jung Hwan ) |
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| Abstract |
PURPOSE
To evaluate the incidence of retinopathy of prematurity (ROP) in premature twins, to determine clinical factors associated with ROP development and to analyze differences in severity of retinopathy of prematurity among siblings of multiple-gestation pregnancies. METHODS: We reviewed the records of 154 neonates of premature twins screened for ROP at one neonatal intensive care unit from January 1, 2000 through December 31, 2002. First, we assessed the frequency of ROP and then, we compared clinical factors between ROP and non-ROP groups. Third, we separated the infants into concordant and discordant ROP groups with discordant group defined as siblings with an intersibling difference of at least two stages of ROP between both siblings with ROP and siblings of one with ROP, another without ROP. Between siblings with discordant ROP, multiple clinical factors were compared. RESULTS: ROP was present in 43.5% of premature twins. Clinical factors significantly related to ROP occurrence were birth weight, duration of mechanical ventilation and duration of oxygen exposure (p<0.05). ROP developed more in groups with hypercarbia, patent ductus arteriosus, bronchopulmonary dysplasia and neonatal respiratory distress syndrome. Among the premature twins, 22.1% had discordant ROP. For those infants with discordant disease, only birth weight was related to occurrence or severity of ROP (p<0.05). CONCLUSIONS: There was no significant difference in incidence and risk factors of ROP between infants of single-gestation pregnancies and those of multiple-gestation pregnancies. Of clinical factors investigated, only birth weight was significantly related to intersibling difference of incidence or severity of ROP in premature twins. |
| Key Words:
Discordant ROP;Multiple-gestation pregnancies;Retinopathy of prematurity;ROP;Twins |
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