The Effect of the Amniotic Membrane and Methocel (R) on the Postoperative Adhesion after Strabismus Surgery.

Lee, Tae Dong; Sin, Min Cheol; Shon, Mi Ah

Original Article

Journal of the Korean Ophthalmological Society 2002;43(2):411-418.
Published online February 1, 2002.

The Effect of the Amniotic Membrane and Methocel (R) on the Postoperative Adhesion after Strabismus Surgery.

Department of Ophthalmology, Chuncheon Sacred Heart Hospital, School of Medicine, Hallym University, Korea. shon829@hallym.or.kr

양막 및 Methocel(R)이 사시 수술 후 유착에 미치는 효과

이태동 ( Tae Dong Lee ) , 신민철 ( Min Cheol Sin ) , 손미아 ( Mi Ah Shon )

Abstract

PURPOSE
To evaluate the effect of amniotic membrane and additional use of 2% methylcellulose(Methocel(R)) in reducing the postoperative adhesions following strabismus surgery. METHODS: Twenty white rabbits (40 eyes) were divided into 4 groups: control group C (12 eyes), trial group A (12 eyes), trial group B (12 eyes), and normal group N (4 eyes). In group C, the superior rectus was detached and scleral scratching was done to provoke a fibrotic reaction, and then, the superior rectus was reattached to the original insertion site. In group A, the above procedure was done and in addition, the superior rectus was covered with two-folded amniotic membrane. In group B, the same procedure was done as in group A and in addition, Methocel(R) was coated between the muscle and adjacent tissues. Eight weeks later, we divided each group into two subgroups. In one group, we examined the degree of adhesion by the blunt dissection between the muscle and adjacent tissues, and in the other group, the histologic findings with a light microscope between the muscle and adjacent tissues. RESULTS: The adhesion degree on the blunt dissection and histologic examination was significantly reduced in groups A and B. But no statistically significant difference between groups A and B was shown in the postoperative adhesion. CONCLUSIONS: From these findings, it is expected that the use of amniotic membrane may reduce the postoperative adhesion after strabismus surgery and theadditional use of Methocel(R) may not be useful.

Key Words: Amniotic membrane;Methylcellulose;Postoperative adhesion