| Clinical Availability of Ophthalmic Tests and PET Neuroimaging in Children with Cortical Visual Impairment. |
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Mi Young Choi, Kyu Hyeong Park, Dong Soo Lee, Young Suk Yu, Jae Sung Lee, Jeong Min Hwang, Dong Gyu Choi |
1Department of Ophthalmology, College of Medicine, Chungbuk National University, Cheongju, Korea.
2Chungbuk National University Medical Research Institute, Cheongju, Korea.
3Department of Nuclear Medicine, College of Medicine, Seoul National University, Korea.
4Department of Ophthalmology, College of Medicine, Seoul National University, Korea. ysyu@snu.ac.kr
5Clinical Research Institute, Seoul National University Hospital, Korea.
6Department of Ophthalmology, College of Medicine, Hallym University, Seoul, Korea. |
| 소아 피질시각장애인에서 안과검사와 PET검사의 임상적 유용성 |
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최미영 ( Mi Young Choi ) , 박규형 ( Kyu Hyeong Park ) , 이동수 ( Dong Soo Lee ) , 유영석 ( Young Suk Yu ) , 이재성 ( Jae Sung Lee ) , 황정민 ( Jeong Min Hwang ) , 최동규 ( Dong Gyu Choi ) |
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| Abstract |
PURPOSE
We performed this study to determine if ophthalmic tests and positron-emission tomography (PET) would have any useful role in the investigation of cortical visual impairment (CVI) in children. METHODS: Ophthalmic tests were performed in children with CVI. After children with CVI and normal volunteers were examined using PET, PET images were transformed spatially on template images using Statistical Parametric Mapping 99 for analysis. The PET images of the CVI patients were compared with those of the normal group to display pixels with significantly decreased metabolism. Glucose metabolism in each patient was compared to that of the normal group and the number of pixels with decreased metabolism in each lobe was counted for analysis. RESULTS: Nine children with CVI showed variable degree of visual acuity. There were two patients with strabismus and one patient with latent nystagmus. In CVI group (n=5), there was a decrease of glucose metabolism in comparison with that of normal group (n=22) in occipital lobe as well as other areas, and the degree of decrease varied widely. The extent of the areas with decreased glucose metabolism in the occipital lobe of each patient ranged widely from 4% to 59%. CONCLUSIONS: The cerebral glucose metabolism was decreased with a variable degree in children with CVI. This result suggests that PET may be helpful in the diagnosis of children with CVI. |
| Key Words:
Children;Cortical visual impairment;FDG-PET;Statistical Parametric Mapping |
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