Immunohistochemical Study of PCNA(Proliferating Cell Nuclear Antigen) in Pterygium.

Min, Jin Bea; Choi, Yong Suk; Kim, Ji Young

Original Article

Journal of the Korean Ophthalmological Society 1999;40(1):70-74.
Published online January 1, 1999.

Immunohistochemical Study of PCNA(Proliferating Cell Nuclear Antigen) in Pterygium.

Jin Bea Min, Yong Suk Choi, Ji Young Kim

Department of Ophthalmology, College of Medicine, Chungbuk National University.

군날개의 PCNA 면역조직화학염색소견

민진배(Jin Bae Min),최용석(Yong Suk Choi),김지영(Ji Young Kim)

Abstract

To investigate cellular proliferation pattern of pterygial tissue, eleven paraffin sections through two normal conjunctiva, six primary and three recurrent pterygia were studied immunohistochemically by finding epithelial cells and subepithelial fibroblasts staining patterns as defined by monoclonal antibody for proliferating cell nuclear antigen(PCNA). The results showed similar epithelial cellular proliferation patterns in normal conjunctiva, primary and recurrent pterygia. But scattered patches of fibroblasts in subepithelial connective tissue staining positive with PCNA were found only in recurrent pterygium. Our results suggest that primary pterygium is not a disorder of excess cellular proliferation, but a proliferation of fibroblasts in subepithelial connective tissue have a role in pathogenesis of recurrent pterygium.

Key Words: Cellular proliferation;Epithelium;Fibroblast;Proliferating cell nuclear antigen;Pterygium