| Effects of Intraoperative Exposure and Postoperative Subconjunctival Injections of 5-fluorouracil in Reducing Adhesions after Strabismus Surgery in Rabbits. |
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Chan Hyeog Whang, Seung Ik Chang, Nam Ju Moon |
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Department of Ophthalmology, National Medical Center. |
| 5-fluorouracil의 수술중 접촉과 술후 추가 결막하 주사 병행요법이 토끼의 사시수술후 유착감소에 미치는 효과 |
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황찬혁(Chan Hyeog Whang),장승익(Seung Ik Chang),문남주(Nam Ju Moon) |
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| Abstract |
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Recently, antimetabolotes such as 5-fluorouracil and mitomycin have been used successfully to reduce postoperative adhesions in animal models after strabismus surgery.Nine rabbits, 18 eyes, 36 areas were divided into 4 groups. The first group was a control one. The second group was treated with 5-fluorouracil intraoperatively. The third group was treated in the same manner as the second group, followed by subconjunctival injections of 5-fluorouracil from postoperative 7th day. The fourth group was treated with mitomycin C intraoperatively.The thied group(booster group) and the fourth group(mitomycin group) were superior to the others in preventing the postoperative adhesions. There was no statistically significant diference in scar length and adhesion grade between booster group and mitomycin group.This study reveals that the subconjunctival injections of 5-fluorouracil after intraoperative contact may reduce postoperative adhesions in secondary strabismus surgery and may prevent the possible serious complications of mitomycin C, giving the similar effect to potent mitomycin C. |
| Key Words:
5-Fluorouracil;Postoperative adhesions;Strabismus surgery |
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