| The Study of Intraocular Vascular Endothelial Growth Factor Concentration in Diabetic Retinopathy after Panretinal Photocoagulation. |
|
Suk Dong Kim, Jong Min Kim, Dong Peal Lee |
|
Dapartment of Ophthalmology, Holy Family Hospital, The Catholic University Medical College. |
| 당뇨망막병증에서 범망막광응고술에 의한 안내 혈관내피성장인자 농도의 변화 |
|
김석동(Suk Dong Kim),김종민(Jong Min Kim),이동필(Dong Peal Lee) |
|
|
|
|
| Abstract |
|
Vascular endothelial growth factor[VEGF] might play important roles in angiogenesis of diabetic retinopathy. Aim of this study is to determine the effect of panretinal photocoagulation[PRP] on the level of VEGF in intraocular fluid of proliferative diabetic retinopathy[PDR]. Aqueous humor was obtained during cataract surgery from 35 eyes of 35 patients with PDR and VEGF concentration was measured using enzyme-linked immunosorbent assay[ELISA]. Patients were classified into 4 groups according to total amount of panretinal photocoagulation[PRP][group A:no PRP, group B: less than 1000 spots, group C: 1000~1500 spots, group D: more than 1500 spots] and VEGF level was analyzed in each group using Spearman's correlation coefficient by rank. Mean concentration of VEGF is 615pg/mlin group A, 307pg/mlin group B, 234 pg/mlin group C, and 136pg/mlin group D. The level of VEGF was significantly lower as total amount of PRP increased[p<0.05]. These findings suggest that therapeutic effect of PRP on PDR can be explained by the reduction of VEGF concentration in intraocular fluid. |
| Key Words:
Proliferative diabetic retinopathy;Panretinal photocoagulation;Vascular endothelial growth factor |
|
PDF Links
Download Citation
