| The Relation of Microalbuminuria with Diabetic Retinopathy in Diabetic Patients without Proteinuria. |
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Jin Chung, Young Ok Kim, Sang Moon Chung |
1Department of Ophthalmology, The Catholic University Medical College, Uijongbu St. Mary's Hospital.
2Department of Internal Medicine, The Catholic University Medical College, Uijongbu St. Mary's Hospital. |
| 단백뇨가 없는 당뇨병 환자에서 미세단백뇨와 당뇨망막병증과의 연관성 |
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정진(Jin Chung),김영옥(Young Ok Kim),정상문(Sang Moon Chung) |
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| Abstract |
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It has been well known that diabetic retinopathy is related to proteinuria in diabetes. However there still remains a controversy regarding the association between microalbuminuria and diabetic retinopathy. To know the effect of microalbuminuria on the development of diabetic retinopathy, we studied the presence of microalbuminuria in 80 diabetic patients who had no proteinuria or a history of renal disease were included in this study. We examined 24 hour microalbuminuria by radioimmunoassay and examined the presence and severity of diabetic retinopathy. Among the total of 80 patients with diabetes, microalbuminuria[20microgram/min] was found in 40%[32 patients] and diabetic retinopathy was in 46.3%[37 patients]. The prevalence of microalbuminuria was higher in diabetic retinopathy group[73.0%, 27 of 37 patients] than in normal control group[11.6%, 5 of 43 patients][p<0.001]. The amount of microalbuminuria showed significant correlation with the severity of diabetic retinopathy[r=0.461, p<0.001]. Duration of diabetes was significantly longer in diabetic retinopathy group than in normal group[10.8+/-5.3 years vs 4.8+/-4.1 years, p<0.001]. There was no statistical significance in blood pressure, fasting blood sugar, HbA1 C, serum cholesterol or lipid between the two groups. With these above results, we suggest that microalbuminuria may be associated with the development of diabetic retinopathy in diabetes and thus, microalbuminuria may be a useful marker for the early detection of diabetic retinopathy. |
| Key Words:
Diabetic retinopathy;Microalbuminuria;Proteinuria |
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