| The Expression of ICAM-1, VCAM-1, & CD44 in Papillae of the Giant Papillary Conjunctivitis. |
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Chan Kyoung Jeong, Tae Hwan Lee, Myoung Kyoo Ko |
1Department of Ophthalmology, Seoul Red Cross Hospital, Seoul, Korea.
2Department of Ophthalmology, College of Medicine, Kwandong University, Myounggi Hospital. |
| 거대유두 결막염 환자의 거대유두에서 ICAM-1, VCAM-1, CD44 의 발현 |
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정찬경(Chan Kyoung Jeong),이태환(Tae Hwan Lee),고명규(Myoung Kyoo Ko) |
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| Abstract |
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Cell Adhesion Molecule(CAM) is a cell surface glycoprotein that plays an important role in many inflammatory reaction. This is responsible for the migration and accumulation of different populations of leukocyte in inflamed tissues. To investigate the relevance of CAM expression to giant papillary conjunctivitis associated with type I and/or type IV hypersensitivity, the histology of conjunctival giant papillae from patients with papillary conjunctivitis was examined with light microscopy and using indirect immunofluorescent staining method with monoclonal antibodies against the ICAM-1, VCAM-1, and CD44. The infiltrates of the inflammatory cells such as eosinophil, basophil, plasma cell and lymphocyte were noted in conjunctival stroma by light microscopy. The ICAM-1, VCAM-1, and CD44 were expressed or upregulated in stroma and vascular wall by immunofluorescent method. These findings suggest that CAM may play a key role in the pathogenesis of giant papillary conjunctivitis. Further efforts to block or modulate the expression of CAMs may provide new therapeutic modalities in the treatment of conjunctival disease. |
| Key Words:
Cell adhesion molecule;Giant papillary conjunctivitis;Immu-nofluorescent method |
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