Plasma PDGF Level as the Risk Factors in diavetic Retinopathy.

Kim, Sun Wook; Kwak, Hyung Woo

Original Article

Journal of the Korean Ophthalmological Society 1998;39(9):2074-2081.
Published online September 1, 1998.

Plasma PDGF Level as the Risk Factors in diavetic Retinopathy.

Sun Wook Kim, Hyung Woo Kwak

Department of Ophthalmology, College of Medicine, Kyunghee University, Seoul, Korea.

당뇨망막병증의 위험인자로서의 혈중 PDGF 농도변화에 대한 연구

김선욱(Sun Wook Kim),곽형우(Hyung Woo Kwak)

Abstract

Although many risk factors were reported, the exact pathogenesis of diabetic retinopathy is still unknown. The platelet derived growth factor(PDGF) is released from platelet alpha granule and plays a major role in wound repair, embryogenesis, and the pathogenesis of artherosclerosis. To evaluate whether serum PDGF may be a risk factors for the development of vascular complications of diabetes mellitus, we reviewed 36 diabetic patients from June 1996 to March 1997. The serum PDGF level was higher in the group of proliferative diabetic retinopathy(23.49+/-23.77pg/ml) and the control group(23.74+/-16.26pg/ml) than in nonproliferative diabetic retinopathy group(19.19+/-18.21pg/ml). The difference was not statistically significant. Patients who had a history of vitrectomy or laser treatment for proliferative diabetic retinopathy had higher serum PDGF level than those with no treatment. We conclude that the PDGF may play a role as one of the risk factors in diabetic retinopathy or their growth factors, and however further study will be required to elucidate the influence of PDGF on the couse of diabetic retinopathy.

Key Words: Diabetic retinopathy;Platelet derived growth factor;Risk factor