Effects of 0.1% Dexamethasone on Experimental corneal Epithelial Healing Following Alkali Wounds.

Kang, Yang Keum; Chung, Jang Hyun

Original Article

Journal of the Korean Ophthalmological Society 1997;38(5):750-755.
Published online May 1, 1997.

Effects of 0.1% Dexamethasone on Experimental corneal Epithelial Healing Following Alkali Wounds.

¹Department of ophthalmology, Ewha Medial Research Center, Ewha Womans University, Seoul, Korea.
²Division of Cell & Tissue Biology, Ewha Medial Research Center, Ewha Womans University, Seoul, Korea.

각막 알카리 화상후 0.1% dexamethasone 국소 점안이 각막 상피의 치유에 미치는 영향

강양금(Yang Keum Kang),정장현(Jang Hyun Chung)

Abstract

The effect of topical steroid on corneal alkali wound has been controversial due to a complexity of its mechanism and a risk of ulceration and perforation. In this study, the effect of topical 0,1% dexamethasone on corneal epithelial wound healing following alkali burn was evaluated quantitatively. 22 eyes wounded by alkali burn out of 22 white rabbits were divided into 3 groups ; A group treated with topical 0.1% dexamethasone for eight weeks, B grouptreated with topical 0.1% dexamethasone for the first one week followed by another seven weeks without treatment, C group with no treatment served as a control. The area of corneal epithelial defect was examined at 6, 18, 30, 42 hours following corneal alkali wound for initial wound healing and examined every other day from 4 days to 48 days following corneal alkali wound for late wound healing. In this study, it was found that topical 0.1% dexamethasone delayed corneal epithelial healing following corneal alkali burn in both stage of initial and late wound healing.

Key Words: Corneal alkali wound;0.1% dexamethasone;Epithelial healing;Rabbit