Histological Changes of the Retinal Following High dose Intravitreal Ganciclovir Injection in Rabbit.

Kim, Jae Suk; Joo, Myung Jin; Yoo, Jin Hyung

Original Article

Journal of the Korean Ophthalmological Society 1997;38(7):1172-1178.
Published online July 1, 1997.

Histological Changes of the Retinal Following High dose Intravitreal Ganciclovir Injection in Rabbit.

Jae Suk Kim, Myung Jin Joo, Jin Hyung Yoo

Department of Ophthalmology, Inje University Seoul Paik Hospital, Seoul, Korea.

유리체내 고용량 Ganciclovir 주입에 의한 가토망막의 조직학적 변화

김재석(Jae Suk Kim),주명진(Myung Jin Joo),유진형(Jin Hyung Yoo)

Abstract

Authors evaluated the retinal toxicity of high dose (2mg/0.1ml, 4mg/0.1ml) intravitreal ganciclovir injection in rabbit eye with light microscopy and electron microscopy. The results were as follows: In twenty-four hours after 2.0mg/0.1ml intravitreal injection group, edema of outer cells in inner nuclear layer were visualized under electron microscopy. These findings were disappeared after 3 days. In 4.0mg/0.1ml intravitreal injection group, edema of outer cells in inner nuclear layer were visualized at 24 hours after injection. Edema of outer cells in inner nuclear layer and axonal swelling of outer plexiform layer and upper border cells of outer nuclear layer were demonstrated at third and seventh day after injection. We observed more severe changes at seventh day than third day, and fragmentation of inner and outer segments in photoreceptor cells and presence of macrophage corresponding site of subretinal space. So, it suggests that 4.0mg/0.1ml intravitreal ganciclovir injection has mild reversible retinal toxicity.

Key Words: Ganciclovir;Intravitreal injection;Retinal toxicity