A Correlation between The Change in The Blood Pressure and Na+ - K+ - ATPase Activity in Spontaneous Hypertensive Rat. |
Kuy Ryong Choi, Chung Sook Ahn, Byung Chae Cho |
Department of Ophthalmology, College of Medicine, Ewha Womans University, Seoul, Korea. |
선천성 고혈압성 흰쥐에서 혈압 변화와 수정체내 Na+- K+-ATPase 활성도의 상관성 |
안정숙(Chung Sook Ahn),조병채(Byung Chae Cho),최규룡(Kuy Ryong Choi) |
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Abstract |
The maintenance of balance between water and electrolyte is essential for keeping the lens transparent. The outflow of the Na+ ion from the membrane and inflow of the K+ ion both of which are sustained by the Na+ - K+ - ATPase, play an important role in maintaining this balance. In this study, by comparing the lens Na+ - K+ - ATPase activity in Spontaneous Hypertensive Rat(SHR) and Sprague-Dawley Rat (SDR), we determined the significance of increase in blood pressure and the change in the enzyme activity after control of blood pressure by administration of Inderal, an anti-hypertensive drug. The Na+ - K+ - ATPase activity was significantly lowered(P<0.01) in the lens of SHR compared to that of SDR. The longer the anti-hypertensive drug was administered and then controlled the blood pressure, the higher the recovery rate of the lowered Na+ - K+ - ATPase activity of SHR, rising up to about 50%. From the results of this study, it is suggested that the activity of lens Na+ - K+ - ATPase may be reversibly recovered after blood pressure control, and that the pathogenesis of high blood pressure-associated cataract may be partially prevented by controlling the blood pressure. |
Key Words:
Blood Pressure;Lens;Na+ - K+ - ATPase;Spontaneous Hypertensive Rat |
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