| Detection of Epidermal Growth Factor Receptor mRNA by in Situ Hybridization in Cataractous Lens Epithelium. |
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Jong Chan Kim, Gye Jong Bae, Jae Ho Kim |
1Department of Ophthalmology, Our Lady of Mercy Hospital, Catholic University, Medical College, Inchon, Korea.
2Department of Ophalmology, Kangnam St. Mary's Hospital, Catholic University, Medical College, Seoul, Korea. |
| 동소 mRNA 보합결합법을 이용한 백내장 수정체 상피내 표피성장인자 수용체의 검출 |
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김종찬(Jong Chan Kim),배계종(Gye Jong Bae),김재호(Jae Ho Kim) |
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| Abstract |
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In this study, we investigated the correlation between the expression of EGFR-mRNA in situ hybridization method and the clinical feature of the cataract. The results were as followed. Nineteen out of fourty six cases(41.3%) were showed the expression of EGFRmRNA in lens epithelium. No correlation between the age of the lenses and the expression of EGFR-mRNA could be demonstrated. The expression of EGFR-mRNA in lens epithelium correlated significantly (P<0.01) with the clinical stage of the cataract. No correlation between the diabetes mellitus and the expression of EGFRmRNA could be demonstated. These results suggest that the EGFR-mRNA status in lens epithelium could be important for the development of the cataract. |
| Key Words:
Epidermal growth facter;Epidermal growth facter recepter;In situ hybridization;Cataractous lens epithelium |
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