The Concentrations of Ascorbic Acid in Vitreous and Subretinal Fluid in Retinal Detachment Patients.

Hong, Sung Bum; Kwon, Oh Woong

Original Article

Journal of the Korean Ophthalmological Society 1995;36(8):1417-1421.
Published online August 1, 1995.

The Concentrations of Ascorbic Acid in Vitreous and Subretinal Fluid in Retinal Detachment Patients.

Sung Bum Hong, Oh Woong Kwon

Department of Ophthalmology, College of Medicine, Yensei University, Seoul, Korea.

열공성 망막박리 환자의 초자체와 망막하액에서의 ascorbic acid 농도

홍성범(Sung Bum Hong),권오웅(Oh Woong Kwon)

Abstract

Ascorbic acid in aqueous humor, the concentration is 15-69 times higher than in plasma, protects ocular tissues from free radicals as an antioxidant and absorbs ultraviolet rays. It is regarded that the concentration of ascorbic acid in the vitreous body is greater than in the plasma, but there is no knowledge about it's role and relationships to retinal disease. We measured the concentrations of ascorbic acid in plasma, aqueous humor, vitreous and subretinal fluid in 10 patients with rhegmatogenous retinal detachment who were treated with scleral encircling by high performance liquid chromatography. The average concentrations of ascorbic acid in plasma, anterior chamber aqueous humor, vitreous, and subretinal fluid were 30.8 +/- 7.5 micro gram/ml, 157.4 +/- 2.5 micro gram/ml, 195.3 +/- 7.5 micro gram/ml, and 178.5 +/- 2.5 micro gram/ml respectively. The ascorbic acid concentrations in intraocular fluids were 5-6 times higher than in plasma.

Key Words: Ascorbic acid;Vitreous;Subretinal fluid;Rhegmatogenous retinal Detachment