The Morphologic Changes of Epikeratoplasty Lenticule In a Case. |
Byung Ro Lee, Myung Kyu Ko, Joon Kiu Choe |
Department of Ophthalmology, School of Medicine Hanyang University, Korea. |
상층각막이식술후 조직렌즈의 조직학적 변화 , 증예보고 |
이병로(Byung Ro Lee),고명규(Myung Kyu Ko),최준규(Joon Kiu Choe) |
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Abstract |
The patients initially underwent epikeratoplasty for keratoconus but a penetrating kerato plasty was required due to the opacity in the cornea. By using of this specimen, which was obtained by trephination the healing process of the host-Ienticule cornea could be examined by electron microscopy and immunofluorescence method. Epithelial ingrowth over the lenticule was well formed by the regeneration of the basement membrane over the Bowman's membrane. However, the poor attachment of the lenticule over the host corneal stroma made the interface easily separated during the sectioning processes. Electron microscopic study revealed the keratocytes in the lenticule stroma vacuolized with large number of degenerated microorganelles. These results suggest that it may take a long time to complete the wound healing of the host-Ienticule interface despite the epithelial ingrowth onto the lenticule was well formed. |
Key Words:
Epikeratoplasty;Extracellular matrix;Keratocyte;Lenticule |