The Effect of Mitomycin on the Experimental Filtering Surgery.

Kim, Woo Jung; Kim, Jee Youn; Youn, Dong Ho

Original Article

Journal of the Korean Ophthalmological Society 1993;34(6):530-539.
Published online June 1, 1993.

The Effect of Mitomycin on the Experimental Filtering Surgery.

Woo Jung Kim, Jee Youn Kim, Dong Ho Youn

¹Department of Ophthalmology, Borame City Hospital, Seoul, Korea.
²Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.

마이토마이신 ( Mitomycin ) 이 실험적 녹내장 누공수술에 미치는 영향

김우중(Woo Jung Kim),김지연(Jee Youn Kim),윤동호(Dong Ho Youn)

Abstract

In tiis study, an expenmental model of glaucoma filtering surgery in rabblts was used to evaluate the effect of single intraoperative application of Mitomycin Full-thickness filtering surgery, posterior lip sclerectomy, was performed after application of 0.5mg/ml Mitomycin-soaked Week-Cel(TM) sponge for 5 minutes in one eye of 15 pigmented rabbits and was irrigated copiously with balanced salt solution(BSS(TM)). The same procedure was done in the contralateral eye as a control, using BSS(TM). In Mitomycin-treated group, the filtering blebs were more prominent with sparse vascular tissues and were maintained through postoperative 8 weeks or more. Histologically, there loas was amount of inflammatory reactions in Mitomycin-treated group. The fibroblastic activity and proliferations of the collagen were also suppessed markedly in Mitomycin-treated group. These results suggest that a single intraoperative application of Mitomycin can be used adjunctively to improve the success rate of glaucoma filtering surgery.

Key Words: Filtering bleb;Glaucoma filtering surgery;Mitomycin