The Inhibitory Effects of 5-fluorouracil on Experimental Proliferative Vitreoretinopathy. |
Kwang Soo Kim, Sung Youl Park, Joon Sup Oh |
Department of Ophthalmology, Keimyung University School of Medicine, Taegu, Korea. |
실험적 증식성 초자체망막증에 대한 5-Fluorouracil 의 억제효과 |
김광수(Kwang Soo Kim),박성렬(Sung Youl Park),오준섭(Joon Sup Oh) |
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Abstract |
Proliferative vitreoretinopathy (PVR) is the main cause of failure in retinal reattachment surgery, Vitrectomy combined with pharmacologic therapy to inhibit proliferating and contracting epiretinal membranes appears to be a promismg approach in the management of PVR. We investigated the inhibitory effect of intravitreal 5-fluorouracil (5-FU) on experimental PVE induced by intravitreal injection of homologous dermal fibroblast in pigmented rabbits. At 6 weeks after intravitreal injection, Goup I (fibroblast only), Group II (early treatment with 1mg of 5-FU), and Group Ill (delayed treatment with 1mg of 5-FU) developed the retinal detachment in 85.7%, 33.3%, and 58.3% respectively. The rate of retinal detachment was lower in treatment groups than in non-treatment group, but there was a statistically significant difference only between non-treatment group (Group I) and early-treatment group (Group II) (p<0.05). In the group that only 5-FU was injected (Group IV), the retinas were preserved in normal clinically and pathologically. These results show that 5-FU may exert a significant anti proliferative effect on intraocular proliferative disorders including PVR especially if the drug is administered more earlier. |
Key Words:
Fibroblast;5- Fluorouracil;Proliferative vitreoretinopathy |
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