The Effect of Topical Dapiprazole on Phenylephrine and Tropicamide-induced Mydriasis.

Lee, Chung Seong; Ji, Nam Cheol

Original Article

Journal of the Korean Ophthalmological Society 1993;34(12):1269-1274.
Published online December 1, 1993.

The Effect of Topical Dapiprazole on Phenylephrine and Tropicamide-induced Mydriasis.

Chung Seong Lee, Nam Cheol Ji

Department of Ophthalmology, Chosun University Hospital, Korea.

Phenylephrine 과 Tropicamide 에 의한 산동 후 Dapiprazole 점안 효과

이충성(Chung Seong Lee),지남철(Nam Cheol Ji)

Abstract

In order to evaluate the effect of topical dapiprazole, an alpha-adrenergic receptor blocker, in reversing mydrisis by 1% tropicamide and 2.5% phenylephrine, we studied 89 subjects. 0.5% dapiprazole in one eye of each subject after full dilatation of both pupils. The pupillary diameter was calibrated, and thereafter statistical analysis was performed with student paired t-test. Thirty minutes after instillation of dapiprazole, there was a highly significant difference of the decreasing rate in pupil size between the dapiprazole treated eyes and the control eyes(p<0.001). The time for complete reversal of mydriasis was also at least 4 hours shorter in the dapiprazole treated eyes than the control eyes(p<0.006). This study suggests that 0.5% dapiprazole is effective in reversing mydriasis caused by 1% tropicamide and 2.5% phenylephrine, and also effective in making the eyes comfortable in a shorter time.

Key Words: Alpha-adrenergic blocker;Dapiprazole;Reversal of mydriasis