Ocular Toxicity of Miconazole in Vitreous Replacement Fluid.

Bae, Hun; Oum, Boo Sup

Original Article

Journal of the Korean Ophthalmological Society 1993;34(12):1227-1233.
Published online December 1, 1993.

Ocular Toxicity of Miconazole in Vitreous Replacement Fluid.

Hun Bae, Boo Sup Oum

Department of Ophthalmology, College of Medicine, Pusan National University, Korea.

초자체강내의 관류한 miconazole 안독성

배훈(Hun Bae),엄부섭(Boo Sup Oum)

Abstract

To determine the ocular toxicity of intravitreal miconazole, we conducted a controlled trial in 20 pigmented rabbit eyes(10 rabbits). An anterior chamber paracentesis was performed on all animals and 0.4 ml of perfluoropropane(C3F8) gas was injected intravitreally. On day three, when it was fully expanded, eyes were underwent C3F8/fluid exchange with vitreous replacement fluid. The infusion solution contained various amounts of miconazole, 0.5 microgram/ml. 1 microgram/ml, 5 microgram/ml, 10 microgram/ml, 50 microgram/ml, 100 microgram/ml and normal saline for control. Intravitreal infusion was performed for 25-30 minuteds and a total of 100-120 ml of fluid was replaced. Histopathological examination revealed retinal toxic reactions in concentrations of 10 microgram/ml or greater. This study suggests that infusion solution of 5 microgram/ml or less is the concentration exceeds the minimal inhibitory concentration for most of fungi and may be safetly used in the treatment of fungal endaphthalmitis.

Key Words: Fungal endophthaIimitis;Miconazole;Ocular toxicity;Vitreous replacement fluid