Clinical Effect of Tissue Plasminogen Activator in Vitreous Hemorrhage.

Im, Young Woo; Moon, Jung Il; Jung, Sang Moon

Original Article

Journal of the Korean Ophthalmological Society 1993;34(11):1135-1140.
Published online November 1, 1993.

Clinical Effect of Tissue Plasminogen Activator in Vitreous Hemorrhage.

Young Woo Im, Jung Il Moon, Sang Moon Jung

Department Ophthalmology, St.Mary's Hospital, Catholic University, Medical College, Seoul, Korea.

초자체 출혈 환자에서 조직형 플라스미노젠 활성제의 임상 효과

임용우(Young Woo Im),문정일(Jung Il Moon),정상문(Sang Moon Jung)

Abstract

There has been several reports that tissue plasminogen activator(tPA) accelerated the fibrinolysis in vitreous cavity in-vivo. We investigated the efficacy of intravitreal tPA injection(25 microgram/100 microgram, 0.1 ml) for treatment of vitreous hemorrhage in non-vitrectomized patients(58 patients, 61 eyes). 1. Visual acuity was improved in 43 eyes(70.5%) and fundus was relatively well seen in 29 eyes(47.5%). 2. There were no clinical differences of intraocular pressure between before injection and the day after injection of tPA. 3, The complication of tPA injection were rebleeding(3 eyes, 4.9%) and inflammatory reaction(1 eyes, 1.6%). On these results, it appears that intravitreal tPA injection is useful for treatment of vitreous hemorrhage before vitrectomy.

Key Words: Tissue plasminogen activator;Visual acuity;Vitreous hemorrhage