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Original Article
Journal of the Korean Ophthalmological Society 1991;32(4):289-293.
Published online April 1, 1991.
Rabltit Model of Acenitine Myelo-optic Neuropathy.
Hee Tae Cho, Sang Ha Kim
Department of Ophthalmology, School of Medicine, Kyung-Pook National University, Taegu, Korea.
아코니틴 수초 시신경병증
조희태(Hee Tae Cho),김상하(Sang Ha Kim)
Abstract
A single sublethal dose of aconitine, a principal constituent of aconite, was administered intraperitoneally to evaluate its toxic effects on the visual pathway, spinal cord and peripheral nerve of the rabbit. Histopathological findings indicate that moderate aconitine poisoning in the rabbit consists primarily of myelopathy. Aconitine is chemically acetyl-benzoyl-ester of aconin, a base derived from quinonline. This fact may explain the similarity of pathologic pictures between subacute myelo-optic neuropathy(SMON) caused by halogenated hydroxyquinoline and acomtine poisoning.
Key Words: aonitine;electron microscopy;myelooptic neuropathy
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