| Concentration of Tobramycin in the Cornea and Sclera After Subconjunctival Injection of Negatively-charged Liposome Encapsulated Tobramycin in Rabbits. |
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Seung Han Han, Eung Kweon Kim, Hong Bok Kim, Hyung Lae Kim |
1Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea.
2Armed Forces Seoul District General Hospital, Korea. |
| 음성전하 liposome 포장 tobramycin 을 정상 가토안에 결막하주사한 후의 tobramycin 의 각막 및 공막내 농도에 관한 연구 |
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김홍복(Hong Bok Kim),한승한(Seung Han Han),김응권(Eung Kweon Kim),김형래(Hyung Lae Kim) |
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| Abstract |
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Bacterial keratitis is a common ophthalmic disease. Recently, topical and subconjunctival therapy were equally effective in reducing the number of viable bacteria in experimental corneal ulcers. Subconjunctival injection produced high but transient concentrations followed by persistent low levels. In contrast, eyedrops produced moderate but sustained concentrations throughout the treatment period. Liposomes are small, biodegradable lipid vesicles with an aqueous core. Incorporation of drugs into liposomes provides a convenient way to retard their release from a relatively inert depot without changing the intrinsic characteristics of the agents. |
| Key Words:
Bacterial keratitis;Liposome-encapsulated tobramycin;subconjunctival injection |
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