Journal of the Korean Ophthalmological Society 1988;29(4):529-533.
Published online April 1, 1988.
The Effect of Ketoconazole in the Treatment of Candida albicans Keratitis in Rabbits.
Won Ki Lee, Hyung Jeon Kim
Department of Ophthalmology, National Medical Center, Seoul, Korea.
가토에서 Candida albicans 각막 궤양에 대한 Ketoconazole 의 치료 효과
이원기(Won Ki Lee),김형전(Hyung Jeon Kim)
Abstract
Candida albicans keratitis was established in rabbits by intrastromal injection of a suspension containing 1.2 X 10(4) spores. After a 48-hour incubation period, the animals were treated with oral ketoconazole(10mg/kg daily) alone and in combination with topical ketoconazole(2% solution ten times a day) for 2 weeks. Clinical scores were significantly lower in both treated groups than in the control group. But there was no significant difference between the two treated groups.


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