| Studies of the Timolol Effect on Intraocular Pressure and Concentration in Aqueous Humor in the White Rabbit. |
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Young Don Oh, Hyung Woo Kwak, Jae Myung Kim |
1Department of Ophthalmology, Nam Seoul Hospital, Korea.
2Department of Ophthalmology, School of Medicine, Kyung Hee University, Seoul, Korea. |
| 백색가토에서 Timolol 의 안압 및 전방내 농도에 대한 효과의 연구 |
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오영돈(Young Don Oh),곽형우(Hyung Woo Kwak),김재명(Jae Myung Kim) |
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| Abstract |
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The effect of 0.25% and 0.5% Timolol on intraocular pressure and concentration in aqueous humor was studied after topical instillation in the white rabbit. The intraocular pressure was measured with pneuma tonometer and the Timolol concentration in aqueous humor was measured with High Preformance Liquid Chromatograph after fine needle aspiration of aqueous humor at various time intervals. The results were as follows; 1. The percentage reduction of intraocular pressure increased with time and reached a peak after 3 hours. 2. The concentration of Timolol in aqueous humor increased with time and reached a peak after 3 hours. 3. There was close correlation between intraocular pressure and Timolol concentration in aqueous humor. |
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