Journal of the Korean Ophthalmological Society 1987;28(6):1239-1245.
Published online June 1, 1987.
The Effect of 5-Fluorouraci1 on the Activity of the Retinal Pigment Epithelium in Vitro.
Myung Kyoo Ko
Department of Ophthalmology, Hanyang University, School of Medicine, Seoul, Korea.
배양된 망막색소상피의 활성화에 5 - fluorouracil 의 영향 및 미세구조관찰
고명규(Myung Kyoo Ko)
Abstract
Fluorouracil Was effective in controlling the in vitro cellular proliferation. When given with cultured human retinal pigment epithelial cell, fluoroirracil decreased the cellular activity of the cultured retinal pigment epithelial cell. The attachment and migratien of the cultured retinal pigment epithelial cell was markedly reduced after repeated treatment with fluorouracil. Electron micrographs of the cultured retinal pigment epithelial cell given with fluorouracil showed marked reduction of cytoplasmic pseudopodia, rupture of plasma membrane, loss of microorganelles and eventual cytolysis. Based on these data, low dose fluorouracil may be an effective inhibitor of the in vitro proliferation of the retinal pigment epithelium.


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