Effeet of Timolol on Aqueous Humor Protein Concentration.

Ahn, Chung Sook

Original Article

Journal of the Korean Ophthalmological Society 1986;27(6):1073-1076.
Published online June 1, 1986.

Effeet of Timolol on Aqueous Humor Protein Concentration.

Chung Sook Ahn

Department of Opthalmology, College of Medicine, Ewha Womans University, Seoul, Korea.

Timolol 이 방수내 단백농도에 미치는 효과

안정숙(Chung Sook Ahn)

Abstract

The Beta-adrenergic blocker(timolol maleate) decreases intraocular pressure by reducing the production of aqueous humor. Twenty patients scheduled to undergo cataract extraction were induced in study. After timolol maleate administration, we found the increase in the total protein concentration. By double-masked controlled study, 0.5% timolol maleate solution and normal saline were applied topically, and aqueous humor was aspirated during surgery. Total protein concentrations were determined by HPGFC. The total protein concentration as well as the concentration of high, medium and low molecular weight protein were elevated in the timololadministrated group. The relation of the levels of the three different molecular weight classes did not differ significantly between the timolol maleate group and the normal group.