Outer Blood-retinal Barrier Alteration Induced by Intraocular Ad vanced Glycation Endproduct. |
Seok Joon Park, Chung Hum Chung |
1Department of Ophthalmology, Seoul Municipal Boramae Hospital. 2Department of Ophthalmology, College of Medicine, Seoul National University. |
토끼 눈 안에 주입된 최종당화산물에 의해 일어나는 외측 망막혈액장벽의 변화 |
박석준(Seok Joon Park),정흠(Hum Chung) |
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Abstract |
Advanced glycation end-product(AGE)is known as a factor causing diabetic retinopathy, but little is known about its effect on the function of outer blood-retinal barrier. To test whether AGE can increase the permeability of outer blood-retinal barrier, we injected glycated albumin into white rabbit eyes and observed the change of the fundus and of the outer blood-retinal barrier permeability. The rabbit retina in medullary ray was thickened in AGE-injected eyes. Intravenously injected microperoxidase, tracer molecule, was found in outer sensory retinal layer and outside of the retinal pigment epithelium in AGE-injected eyes. These results suggest that intraocularly injected AGE can increase the outer blood-retinal barrier permeability. |
Key Words:
Advanced glycation endproduct;Outer blood-retinal barrier;Permeability |