| Efficacy of Intraoperative Mitomycin C Eye Drops during and after Dacryocystorhinostomy for Canalicular Obstruction. |
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Yu Jin Choi, Seong Jae Kim, Ji Myong Yoo, Seong Wook Seo |
1Department of Ophthalmology, Gyeongsang National University School of Medicine, Jinju, Korea. stramast@naver.com
2Gyeongsang Institute of Health Science, Gyeongsang National University, Jinju, Korea. |
| 눈물주머니코안연결술을 시행한 눈물소관폐쇄에서 수술 중과 수술 후 사용한 마이토마이신 C 효과 |
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최유진1⋅김성재1,2⋅유지명1,2⋅서성욱1,2 |
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경상대학교 의과대학 안과학교실1, 경상대학교 건강과학연구원2 |
Correspondence:
Seong Wook Seo
Email: stramast@naver.com |
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Received: 15 March 2018 • Revised: 26 June 2018 • Accepted: 26 September 2018 |
| Abstract |
PURPOSE
This study investigated the efficacy of intraoperative and postoperative mitomycin C eye drops in patients with canalicular obstructions. METHODS: In total, 46 eyes of 46 patients diagnosed with canalicular obstruction at our hospital between June 2012 and June 2016 were analyzed. Canalicular trephination was done and, after applying 0.02% mitomycin C for 3 minutes on the exposed lacrimal sac during endoscopic dacryocystorhinostomy, the area was washed with 20 mL of saline solution, and a silicon tube was inserted. On postoperative day 1, an antibiotic eye drop was applied; beginning on postoperative day 2, 0.02% mitomycin C eye drops were applied, and 0.5% steroid eye drops were applied. Pre- and postoperative anterior segment optical coherence tomography was used to measure the nasal, central, and lateral tear meniscus heights. The extent of functional improvement was assessed by measuring the degree of tear according to Munk's score, and anatomical improvement was assessed using a syringing test. RESULTS: The nasal tear meniscus height decreased from 571.64 ± 260.51 µm to 267.16 ± 59.25 µm (p = 0.043); central tear meniscus height from 580.16 ± 186.24 µm to 271.14 ± 45.10 µm (p = 0.018); and lateral tear meniscus height from 480.52 ± 260.23 µm to 220.16 ± 63.79 µm (p = 0.029). The functional success rate was 93.5% (43/46), and the anatomical success rate was 95.7% (44/46). CONCLUSIONS: Intraoperative and postoperative mitomycin C and steroid eye drops may be an effective treatment for canalicular obstruction patients and should help increase surgical success rates. |
| Key Words:
Dacryocystorhinostomy;Lacrimal canaliculus;Mitomycin C |
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