| Thyroid Abnormality and Dry Eye Syndrome: a Cross-sectional Study from the Republic of Korea. |
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Yeseul Kim, Jin Kwon Chung, Si Hyung Lee |
1Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. sieh12@schmc.ac.kr
2Department of Ophthalmology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea. |
| 갑상선 이상과 건성안의 관계: 제5기 국민건강영양조사 자료 |
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김예슬1 · 정진권2 · 이시형1 |
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순천향대학교 의과대학 부천병원 안과학교실1, 순천향대학교 의과대학 서울병원 안과학교실2 |
Correspondence:
Si Hyung Lee,
Email: sieh12@schmc.ac.kr
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Received: 31 January 2019 • Revised: 11 April 2019 • Accepted: 18 July 2019 |
| Abstract |
PURPOSE
To investigate the relationship between thyroid abnormality and dry eye syndrome (DES) in a nationally representative Korean population. METHODS: A population-based prospective cross-sectional study was conducted, using the thyroid abnormality data set of the Korean National Health and Nutrition Examination Survey, 2010 – 2012. A total of 16,966 Korean participants with DES were enrolled in the study. RESULTS: The DES patients were predominantly women, non-smokers and non-drinkers, living in urban regions, with a low income and body mass index (BMI), and with a higher percentage of hypertension, hyperlipidemia, thyroid abnormalities, thyroid diseases, and thyroid cancers. After adjusting for all significant variables, thyroid abnormality (odds ratio [OR], 1.93; 95% confidence interval [CI], 1.43–2.61), thyroid disease (OR, 1.85; 95% CI, 1.37–2.52), and thyroid cancer (OR, 2.45; 95% CI, 1.06–5.67) were significantly associated with DES. There was also a significant association between DES and thyroid abnormalities (OR, 2.02; 95% CI, 1.47–2.76), thyroid diseases (OR, 1.93; 95% CI, 1.41–2.65), and thyroid cancer (OR, 2.62; 95% CI, 1.06–6.62) in the female group, but there was no significant association in the male group. CONCLUSIONS: Thyroid abnormalities, thyroid diseases, and thyroid cancers were associated with DES in a nationally representative Korean population. Close evaluation of thyroid abnormalities is therefore needed when treating female patients. |
| Key Words:
Dry eye syndrome;Thyroid cancer;Thyroid disease |
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