Clinical Significance of Tear Film Osmolarity for Non-Sjögren Dry Eye Diagnosis.

Yun, Jun Myeong; Yim, Hye Bin; Kim, Hyun Seung; Na, Kyung Sun

doi:2017.58.6.640

J Korean Ophthalmol Soc > Volume 58(6); 2017 > Article

Original Article

Journal of the Korean Ophthalmological Society 2017;58(6):640-645.
DOI: https://doi.org/10.3341/jkos.2017.58.6.640 Published online June 15, 2017.

Clinical Significance of Tear Film Osmolarity for Non-Sjögren Dry Eye Diagnosis.

Jun Myeong Yun, Hye Bin Yim, Hyun Seung Kim, Kyung Sun Na

¹Department of Ophthalmology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.
²Department of Ophthalmology and Visual Science, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. drna@catholic.ac.kr

비쇼그렌 건성안 환자의 진단에서 눈물막 삼투압 측정의 임상적 유의성

윤준명¹⋅임혜빈¹⋅김현승²⋅나경선²

가톨릭대학교 의과대학 인천성모병원 안과학교실¹, 가톨릭대학교 의과대학 여의도성모병원 안과 및 시과학교실²

Correspondence: Kyung Sun Na,
Email: drna@catholic.ac.kr

Received: 9 February 2017 • Revised: 27 March 2017 • Accepted: 19 May 2017

Abstract

PURPOSE
To evaluate the diagnostic value of tear film osmolarity for non-Sjogren dry eye syndrome through measuring the correlation between tear osmolarity and several conventional dry eye parameters. METHODS: In this observational cross-sectional study, 274 patients (274 eyes) with non-Sjogren dry eye syndrome were examined using tear film osmolarity and the following conventional dry eye parameters: Schirmer's test, tear film break-up time, ocular surface disease index (OSDI), and corneal staining score. The correlations between tear film osmolarity and each conventional dry eye parameter were assessed using Spearman's correlation coefficients. RESULTS: The mean tear film osmolarity of the study population was 296.34 ± 21.08 mOsm/L. The tear film osmolarity was significantly negatively correlated with the Schirmer's test value (r = -0.431, p < 0.001) and tear break-up time (r = -0.131, p = 0.031), while it was significantly positively correlated with the OSDI scores (r = 0.191, p = 0.001) and corneal staining scores (r = 0.150, p = 0.013). CONCLUSIONS: Tear film instability was significantly correlated with other conventional dry eye parameters. However, additional studies are required to determine its feasibility as a stand-alone diagnostic tool.

Key Words: Non-sjogren dry eye;Schirmer's test;Tear film osmolarity