| Pharmacologic Effects of Atropine Penalization in Amblyopic Eyes. |
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Sun Ho Park, Sae Mi Park, A Ran Cho, Song Hee Park |
1Department of Ophthalmology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea. scheye@hosp.sch.ac.kr
2Pureun Eye Clinic, Gwangju, Korea.
3Seoul St. Mary's Eye Hospital, Suwon, Korea. |
| 약시안에서 아트로핀 처벌치료의 약리 효과 |
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박선호1⋅박새미2⋅조아란3⋅박성희1 |
Department of Ophthalmology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine1, Seoul, Korea
Pureun Eye Clinic2, Gwangju, Korea
Seoul St. Mary’s Eye Hospital3, Suwon, Korea |
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| Abstract |
PURPOSE
To analyze the pharmacologic effect of atropine penalization in amblyopic eyes. METHODS: Distant and near visual acuity, near point of accommodation (NPA), and pupil size were measured in the sound eye of 40 children with amblyopia before and after receiving atropine sulfate 1% solution. Amblyopic children were divided into 2 groups according to the time of follow-up visit: 4-days and 7-days after injection; the same tests were performed on all the scheduled follow-up visits. This study included a control group of 20 normal children who received the same test on the initial visit and the scheduled follow-up visits. RESULTS: Visual acuity of the sound eye at distance showed greater decreases in children with 4-day follow-up visits compared with 7-day visits in the amblyopic group (p = 0.24). There was no significant difference in near visual acuity between the amblyopic group and the normal control group by follow-up interval (p = 0.98, p = 0.75). Near point of accommodation significantly increased in the 4-day visit group in both the amblyopic and the normal control groups (p = 0.04 and p = 0.03, respectively), Pupil size was significantly maintained in the 4-day visit, amblyopic group (p = 0.01). CONCLUSIONS: Atropine effectively decreased the vision of the sound eye in amblyopic children. However, to maintain the pharmacologic effect, two separate atropine instillations per week (on a weekday and the weekend) should be considered as a treatment for amblyopia. |
| Key Words:
Amblyopia;Atropine penalization treatment;Weekend atropine |
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