Paradoxical Trichomegaly of the Eyelashes During Treatment with EGFR Inhibitors: 2 Case Report.

Na, Kun Hoo; Eom, Young Sub; Kang, Su Yeon; Kim, Hyo Myung; Song, Jong Suk

doi:2014.55.6.908

J Korean Ophthalmol Soc > Volume 55(6); 2014 > Article

Case Report

Journal of the Korean Ophthalmological Society 2014;55(6):908-912.
DOI: https://doi.org/10.3341/jkos.2014.55.6.908 Published online June 15, 2014.

Paradoxical Trichomegaly of the Eyelashes During Treatment with EGFR Inhibitors: 2 Case Report.

Kun Hoo Na, Young Sub Eom, Su Yeon Kang, Hyo Myung Kim, Jong Suk Song

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea. crisim@korea.ac.kr

항암치료를 위해 사용된 표피성장인자 수용체 억제제로 유발된 긴속눈썹증 2예

나건후⋅엄영섭⋅강수연⋅김효명⋅송종석

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea

Abstract

PURPOSE
To introduce 2 cases of trichomegaly associated with the use of systemic epidermal growth factor receptor (EGFR) inhibitors for the treatment of lung cancer. CASE SUMMARY: An 82-year-old female visited our clinic for ocular pain in both eyes. She was suffering from metastatic lung cancer and was under daily treatment with gefitinib (Iressa(R), AstraZeneca, London, UK) for 6 months. On ophthalmologic examination, she presented with abnormally elongated eyelashes, hyperemic conjunctiva and dense corneal erosion. A 52-year-old male who was diagnosed with non-small cell lung cancer 7 months before and treated with erlotinib (Tarceva(R) OSI Pharmaceuticals, Inc., Melville, NY, USA) was referred to our clinic for injection and foreign body sensation in both eyes. Although there were no remarkable changes in eyelashes at the initial visit, long, curly, uneven eyelashes were observed after 3 months. CONCLUSIONS: Due to the increased use of EGFR inhibitors in anti-cancer treatment, ophthalmologists should be aware of these chemotherapeutics' adverse effects.

Key Words: Epidermal growth factor receptor inhibitor;Trichomegaly