| Clinicopathological Report of Squamous Cell Carcinoma of Conjunctiva and Cornea in a Patient with AIDS. |
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Min Kyu Yang, Bo Hyuk Kim, Mee Kum Kim, Won Ryang Wee, Joo Youn Oh |
1Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. jooyounoh77@gmail.com
2Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea. |
| 후천성 면역 결핍증 환자에서 발생한 각결막의 편평세포암 1예 |
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양민규⋅김보혁⋅김미금⋅위원량⋅오주연 |
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Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine1, Seoul, Korea Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute2, Seoul, Korea |
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| Abstract |
PURPOSE
To describe the clinical and histopathological findings of corneal and conjunctival squamous cell carcinoma (SCC) in a patient with acquired immune deficiency syndrome (AIDS). CASE SUMMARY: A 45-year-old Korean male who had been diagnosed of AIDS 20 years before presented with vascularized mass in the inferotemporal conjunctiva and in the cornea. The patient underwent an en bloc excisional biopsy of the mass, application of mitomycin C, and repeated cycles of freeze-thaw. Histopathology revealed dysplastic squamous epithelium in the full thickness of epithelial layer. Immunohistochemical staining for proliferation markers showed that the tumor had a high proliferation index: Ki-67 was positive throughout the full epithelial layer, and both p53 and p16 were positive. The patient had an adjuvant chemotherapy with topical interferon alpha 2b (IFNalpha 2b) for 8 months after surgery. CONCLUSIONS: Given the high proliferation index of the tumor in this patient, close observation and combined adjuvant chemotherapy will be required to prevent recurrence in a patient with AIDS. |
| Key Words:
Acquired immune deficiency syndrome;Conjunctiva;Cornea;Squamous cell carcinoma |
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