| Effect of Topical 0.05% Cyclosporine A in Dry Eye Associated With Thyroid Ophthalmopathy. |
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Won Choi, Yeoung Geol Park, Jae Kap Cho, Kyung Chul Yoon |
1Department of Ophthalmology, Chonnam National University Hospital, Medical School, Gwangju, Korea. kcyoon@chonnam.ac.kr
2Department of Ophthalmology, Seonam University College of Medicine, Namwon, Korea. |
| 건성안을 동반한 갑상샘안병증에서 0.05% 사이클로스포린 A 점안액 사용 후 눈물막과 안구표면의 변화 |
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최원1ㆍ박영걸1ㆍ조재갑2ㆍ윤경철1 |
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Department of Ophthalmology, Chonnam National University Hospital, Medical School1, Gwangju, Korea Department of Ophthalmology, Seonam University College of Medicine2, Namwon, Korea |
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| Abstract |
PURPOSE
The present study was performed to evaluate the changes in tear film and ocular surface parameters after using sodium hyaluronate (SH) 0.1% alone or in combination with cyclosporine A (CsA) 0.05% in patients with thyroid-associated ophthalmopathy accompanied by dry eye. METHODS: A total of 72 eyes from 36 patients were divided into two groups; 36 eyes of 18 patients were treated with 0.1% SH alone (group 1), and 36 eyes of 18 patients were treated with SH 0.1% and CsA 0.05% (group 2). Tear break-up time (BUT), basal tear secretion test (BST), tear clearance rate (TCR), fluorescein staining (FS) and corneal sensitivity test (CST) were evaluated at pre-treatment and one, three and six months post-treatment. Conjunctival impression cytology was performed and tear CXCL11 (Chemokine (C-X-C motif) ligand) levels were measured pre-treatment and three months post-treatment. RESULTS: BUT, BST, TCR, KEP and CST were significantly improved at six months in group 1 (p < 0.05) and at three months in group 2 (p < 0.05). The degree of conjunctival squamous cell metaplasia, goblet cell density and tear CXCL11 levels were significantly changed at three months in group 2 (p < 0.05). However, there were no significant changes in group 1 after 3 months. CONCLUSIONS: Combined use of topical 0.1% SH and 0.05% CsA can result in early improvement in tear films and ocular surface parameters in patients with thyroid-associated ophthalmopathy accompanied by dry eye. |
| Key Words:
Cyclosporine;Dry eye syndrome;Sodium hyaluronate;Thyroid associated ophthalmopathy |
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