| Long-term Evaluation After Topical Cyclosporine Treatment in Dry Eye Patients With Graft-Versus-Host Disease. |
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Seung Hyun Lee, Seoung Kyu Im, Je Moon Woo, Kyung Chul Yoon |
1Department of Ophthalmology, Chonnam National University Medical School, Gwangju, Korea. kcyoon@chonnam.ac.kr
2Department of Ophthalmology, Ulsan Hospital, Ulsan University Medical School, Ulsan, Korea. |
| 건성안이 있는 이식편대숙주질환에서 사이클로스포린 A 점안치료 후 장기간의 경과관찰 |
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이승현1ㆍ임성규1ㆍ우제문2ㆍ윤경철1 |
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Department of Ophthalmology, Chonnam National University Medical School1, Gwangju, Korea / Department of Ophthalmology, Ulsan Hospital, Ulsan University Medical School2, Ulsan, Korea |
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| Abstract |
PURPOSE
This study was performed to evaluate the long-term effect of 0.05% cyclosporine A emulsion (Restasis, Allergan Inc. USA.) on dry eye associated with graft-versus-host disease (GVHD). METHODS: Sixteen eyes of 8 patients with severe dry eye associated with GVHD were treated with 0.05% cyclosporine A emulsion twice a day. Tear film parameters were evaluated before treatment and after 1, 3, 6, and 12 months of treatment. RESULTS: One month after treatment, tear break-up time improved from 3.88+/-1.78 s to 4.17+/-1.90 s (P=0.02). Three months after treatment, symptom score and basal secretion improved from 3.00+/-0.38 and 4.44+/-1.59 mm to 2.33+/-0.52 (P=0.04) and 5.42+/-2.50 mm (P=0.04), respectively. Twelve months after treatment, the keratoepitheliopathy score improved from 2.38+/-1.31 to 1.13+/-0.35 (P=0.02). CONCLUSIONS: Use of a 0.05% cyclosporine A emulsion is effective for dry eye associated with GVHD as it helps to increase tear secretion and to relieve symptoms. Treatment with 0.05% cyclosporine A emulsion for longer than 1 year may be necessary to improve keratoepitheliopathy. |
| Key Words:
Cyclosporine;Dry eye syndrome;Graft-versus-host disease |
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