| Evaluation of the Prophylactic Use of Mitomycin to Inhibit Haze Formation after LASEK. |
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Eung Suk Kim, Kyung Hyun Jin |
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Department of Ophthalmology, KyungHee University College of Medicine, Seoul, Korea. khjinmd@khmc.or.kr |
| -5.0~-8.5디옵터의 근시안에서 라섹(LASEK) 수술시 사용한 저농도 마이토마이신의 각막혼탁억제 효과 |
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김응석,진경현 |
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Department of Ophthalmology, KyungHee University College of Medicine, Seoul, Korea |
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Correspondence:
Eung Suk Kim, M.D. |
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| Abstract |
PURPOSE
To evaluate the effects of the prophylactic use of mitomycin C in low concentration and short duration (0.01%, 60 sec) in inhibiting haze formation after laser epithelial keratomileusis (LASEK). METHODS: Forty-two eyes of 71 patients with refractive error from -5.0 D to -8.50 D were enrolled in this study. The eyes were divided into 2 groups according to the use of mitomycin C. All eyes were examined for refraction, UCVA, BCVA, and the incidence and degree of corneal haze before surgery and at 1, 3, 6 months after operation. RESULTS: Fifty-one eyes were operated by LASEK with intraoperative application of 0.01% mitomycin C for 60 seconds and 20 eyes were operated by LASEK without mitomycin C. There was no statistical difference in UCVA, BCVA, and spherical equivalent between 2 groups. In the study group, the degree of corneal haze was 0.54+/-0.39. 0.38+/-0.48, 0.30+/-0.50 at 1, 3, 6 months after operation and in the control group, 0.92+/-0.58, 0.79+/-0.66, 0.50+/-0.60 at 1, 3, 6 months after operation respectively. The difference in the postoperative corneal haze between 2 groups was statistically significant at 1, 3 months after operation, but at 6 months the difference was not statistically significant. CONCLUSIONS: In this study, intraoperative single use of mitomycin C in lower concentration and short duration could reduce the formation of corneal haze effectively in early postoperative period after LASEK. A more longterm period of follow up will be required to assess the continuous effect of mitomycin C on inhibiting corneal haze after LASEK. |
| Key Words:
Mitomycin C;Corneal haze;LASEK |
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