| Effects of Neodymium:YAG Laser and Tissue Plasminogen Activator on Massive Diabetic Premacular Hemorrhage. |
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Young Hoon Park, Won Ki Lee, Jin Chung, Hyun Seung Kim, Young Chun Lee |
1Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Seoul, Korea. leeyc@cmc.cuk.ac.kr
2St. Mary's Eye Clinic, Uijeongbu, Korea. |
| 다량의 당뇨성 황반전출혈에 대한 야그레이저와 조직형플라스미노젠 활성제의 병합치료 효과 |
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박영훈1,이원기1,정진2,김현승1,이영춘1 |
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Department of Ophthalmology, College of Medicine, The Catholic University of Korea1, Seoul, Korea, St. Mary??s Eye Clinic2, Uijeongbu, Korea |
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Correspondence:
Young Hoon Park, M.D.1 |
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| Abstract |
PURPOSE
To investigate the combined therapeutic effects of Neodymium:YAG (Nd:YAG) laser membranotomy and intravitreal tissue plasminogen activator (tPA) on massive diabetic premacular hemorrhage. METHODS: The authors performed Nd:YAG laser membranotomy on the hemorrhagic membrane of premacular hemorrhages and injected tPA (25 microgram) into the vitreous cavity of 5 eyes with massive diabetic premacular hemorrhage. Each time, 0.2 ml of perfluoropropane (C3F8) gas was also injected. RESULTS: After Nd:YAG laser membranotomy and tPA injection, the patients' vision recovered within 4 weeks and the hemorrhages were completely absorbed within 8 weeks. Visual acuity at the last visit had improved to a mean of 10 lines (8-13 lines) on ETDRS charts for all cases. There were no associated ophthalmic complications. Also, there were no cases that required vitrectomy. CONCLUSIONS: Combined therapy of Nd:YAG laser membranotomy and tPA injection with an expansive gas is a good alternative method to observation or simple Nd:YAG laser treatment for resolution of premacular hemorrhages in proliferative diabetic retinopathy patients, and may allow for faster resolution of hemorrhages without the complications of vitrectomy. |
| Key Words:
Nd:YAG laser;Premacular hemorrhage;Tissue plasminogen activator |
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