Photodynamic Therapy of Choroidal Neovasculariation Associated with Large Serous Pigment Epithelial Detachment.

Han, Jung Won; Lee, Won Ki

Original Article

Journal of the Korean Ophthalmological Society 2004;45(1):79-86.
Published online January 1, 2004.

Photodynamic Therapy of Choroidal Neovasculariation Associated with Large Serous Pigment Epithelial Detachment.

Department of ophthalmology, Kangnam St. Mary's Hospital, School of Medicine, The Catholic University of Korea. wklee@catholic.ac.kr

큰 장액 망막색소상피박리가 동반된 맥락막신생혈관에 대한 광역학치료의 효과

한정원 ( Han Jeong Won ) , 이원기 ( Lee Won Gi )

Abstract

PURPOSE
To evaluate the efficacy of photodynamic therapy of choroidal neovascularization (CNV) associated with large serous pigment epithelial detachment (PED) in eyes with age-related macular degeneration. METHODS: The records of nine eyes of nine patients were reviewed. Mean follow-up period was 11.4 months (range, 6 ~ 26 months). The photodynamic therapy was done using a spot size with a diameter larger than the greatest linear dimension of the CNV lesion revealed on indocyanine green angiography (ICGA). RESULTS: In 7 of 9 eyes, the PED persisted with progression of neovascular membrane, and retinal pigment epithelial tear occurred in 3 eyes. In one eye, visual improvement could be achieved with decreased extent of PED until the follow up period of 6 months. In remaining one eye, the caliber of new vessel decreased on ICGA accompanied by improvement of vision and PED after first photodynamic therapy. However, 3 months after second photodynamic therapy, CNV proliferated extensively with resultant visual loss. CONCLUSIONS: The results of our study suggest that photodynamic therapy provide no benefit in the treatment of CNV associated with large serous PED in age-related macular degeneration.

Key Words: Choroidal Neovascularization;Photodynamic Therapy;Pigment Epithelial Detachment