Therapeutic Effect of Topical Autologous Serum in Recurrent Punctate Corneal Erosion.

Han, Myeong Soo; Lee, Jong Hyuck; Lee, Seok Joon

Original Article

Journal of the Korean Ophthalmological Society 2004;45(10):1639-1644.
Published online October 1, 2004.

Therapeutic Effect of Topical Autologous Serum in Recurrent Punctate Corneal Erosion.

Myeong Soo Han, Jong Hyuck Lee, Seok Joon Lee

Department of Ophthalmology, Wonju Christian Hospital, Yonsei University, Wonju College of Medicine, Wonju, Korea. jhlee@w.y.ac.kr

반복성 점상 각막미란에서 자가혈청 국소점안의 치료효과

한명수 ( Myeong Soo Han ) , 이종혁 ( Jong Hyuck Lee ) , 이석준 ( Seok Joon Lee )

Abstract

PURPOSE
To study the effect of topical autologous serum in the treatment of recurrent punctate corneal erosions. METHODS: A total of 10 eyes from recurrent corneal erosion patients, who had suffered from recurrence after initial treatment with conventional therapy were treated using topical autologous serum from October 2001 to April 2003. We investigated the efficacy of this method over conventional therapy by retrospective review of their medical records. RESULTS: The recurrence rate of erosions before treatment with autologous serum eyedrops ranged from once every 2months to twice a month. Mean follow-up time was 11.0 +/- 4.6 months (range, 6~19 months). There was one case of recurrence 3 months after first treatment with autologous serum eyedrops which was effectively cured with autologous serum eyedrops. No side effects were noted in any of the treated patients. CONCLUSIONS: Topical autologous serum application may be considered as an effective and safe treatment modality in recurrent corneal erosions.

Key Words: Autologous serum;Conventional therapy;Recurrent punctate corneal erosion