The Relationship between Plasma PAI-1 Antigen Concent ration and Diabetic Retinopathy in NIDDM Patients.

Seo, Jeong Bong; Yoo, Jin Seong; Huh, Warne

Original Article

Journal of the Korean Ophthalmological Society 2000;41(1):127-132.
Published online January 1, 2000.

The Relationship between Plasma PAI-1 Antigen Concent ration and Diabetic Retinopathy in NIDDM Patients.

Jeong Bong Seo, Jin Seong Yoo, Warne Huh

Department of Ophthalmology, Kangnam St.Mary's Hospital, College of Medicine, The Catholic University of Korea.

인슐린 비의존형 당뇨환자에서의 혈장 PAI - 1 항원농도와 당뇨망막병증의 상관관계

서정봉(Jeong Bong Seo),유진성(Jin Seong Yoo),허원(Warne Huh)

Abstract

To examine the relationship between plasma plasminogen activator inhibitor-1[PAI-1]antigen concentration and diabetic retinopathy in non-insulin dependent diabetic patients, PAI-1 antigen levels and some fibri-nolytic parameters were studied in 89 non-insulin dependent diabetic patients[mean age 59.8 +/-11.3 years]and 25 normal adults as control[meanage 52.8 +/-14.7 years]. The diabetic patients were classified as three subgroups: no DR[n=34], NPDR[n=29]and PDR[n=26]according to the degree of retinopathy.The PAI-1 antigen concentration was measured by enzyme immunoassay[Innotest PAI Ag kit].The diabetic patients had a significantly higher mean PAI-1 antigen level [34.56 +/-17.80ng/milliliter ]compared to a control group[20.35 +/-15.78 ng/milliliter ][p<0.05].Plasma PAI-1 antigen level was significantly lower in diabetic patients with PDR[27.39 +/-15.54 ng/milliliter ]than in diabetics with no DR[36.87 +/-23.31 ng /milliliter ]or NPDR[39.43 +/-2 0.17 ng/milliliter ][p<0.05], probably because of more extensive systemic endothelial damage. These results support the hypothesis that impaired fibrinolysis due to elevated PAI-1 is associated with the development of retinopathy, and therefore the levels of PAI-1 can be used as useful indicator for the development and progression of proliferative retinopathy.

Key Words: Diabetic retinopathy;NIDDM;Plasma PAI-1