A Correlation between The Change in The Blood Pressure and Na+ - K+ - ATPase Activity in Spontaneous Hypertensive Rat.

Choi, Kuy Ryong; Ahn, Chung Sook; Cho, Byung Chae

Original Article

Journal of the Korean Ophthalmological Society 1995;36(6):960-966.
Published online June 1, 1995.

A Correlation between The Change in The Blood Pressure and Na+ - K+ - ATPase Activity in Spontaneous Hypertensive Rat.

Kuy Ryong Choi, Chung Sook Ahn, Byung Chae Cho

Department of Ophthalmology, College of Medicine, Ewha Womans University, Seoul, Korea.

선천성 고혈압성 흰쥐에서 혈압 변화와 수정체내 Na+- K+-ATPase 활성도의 상관성

안정숙(Chung Sook Ahn),조병채(Byung Chae Cho),최규룡(Kuy Ryong Choi)

Abstract

The maintenance of balance between water and electrolyte is essential for keeping the lens transparent. The outflow of the Na+ ion from the membrane and inflow of the K+ ion both of which are sustained by the Na+ - K+ - ATPase, play an important role in maintaining this balance. In this study, by comparing the lens Na+ - K+ - ATPase activity in Spontaneous Hypertensive Rat(SHR) and Sprague-Dawley Rat (SDR), we determined the significance of increase in blood pressure and the change in the enzyme activity after control of blood pressure by administration of Inderal, an anti-hypertensive drug. The Na+ - K+ - ATPase activity was significantly lowered(P<0.01) in the lens of SHR compared to that of SDR. The longer the anti-hypertensive drug was administered and then controlled the blood pressure, the higher the recovery rate of the lowered Na+ - K+ - ATPase activity of SHR, rising up to about 50%. From the results of this study, it is suggested that the activity of lens Na+ - K+ - ATPase may be reversibly recovered after blood pressure control, and that the pathogenesis of high blood pressure-associated cataract may be partially prevented by controlling the blood pressure.

Key Words: Blood Pressure;Lens;Na+ - K+ - ATPase;Spontaneous Hypertensive Rat